glutathione reductase pathway gene peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 and resisted autophagy-related ferroptosis via Glutathione (GSH) and antioxidant enzymes,

A key approach involves inhibiting enzymes like ACSL4, which incorporates polyunsaturated fatty acids into membranes, a critical step for ferroptosis (Ou, 2024

Overall the above reported evidence on the involvement of GSH and the redox environment are only some issues that deserve to be further investigated to comprehend the several aspects characterizing the possible crosstalk between redox reactions and modulation of ATG

and the use of antivirals that enhance activation of the Nrf2 transcription factor together with N-acetylcysteine administration restore GSH levels correcting the SARS-CoV-2-mediated impaired GSH metabolism (Aquilano et al., 2014

Minimizing and managing side effects Proactive strategies reduce the likelihood of side effects and help manage any that occur